Individual Growth Curve Analysis of APOE ε4–Associated Cognitive Decline in Alzheimer Disease

APOE 4 allele predicts faster cognitive decline in mild Alzheimer disease

Methods: Individuals were recruited from two longitudinal cohort studies—the Washington Heights and Inwood Columbia Aging Project (WHICAP; population-based) and the Predictors Study (clinic-based)—and were followed for an average of 4 years. Three samples of participants diagnosed with AD, with diverse demographic characteristics and baseline cognitive functioning, were studied: 1) 199 (48%) of...

Cognitive decline in prodromal Alzheimer disease and mild cognitive impairment.

OBJECTIVE To characterize the course of cognitive decline during the prodromal phase of Alzheimer disease. DESIGN Longitudinal cohort study with up to 16 years of observation. PARTICIPANTS Older persons from 2 studies underwent annual clinical evaluations that included cognitive function testing and clinical classification of mild cognitive impairment, dementia, and Alzheimer disease. At ba...

ReportAntibodies against - Amyloid Slow Cognitive Decline in Alzheimer ’ s Disease

Leisure activity and cognitive decline in incident Alzheimer disease.

BACKGROUND High rates of leisure activity have been associated with reduced risk of Alzheimer disease (AD). OBJECTIVE To determine whether prediagnosis leisure activity modifies the rate of cognitive decline in patients with AD. DESIGN Inception cohort followed up longitudinally for a mean of 5.3 years (up to 13.9 years). SETTING Urban community. PARTICIPANTS A total of 283 patients wit...

Cerebrovascular reactivity and cognitive decline in patients with Alzheimer disease.

BACKGROUND AND PURPOSE The aim of this study was to explore the possible contribution of alterations in cerebral hemodynamics to the evolution of cognitive impairment in patients with Alzheimer disease (AD). METHOD Fifty-three patients with AD were investigated. The evolution of cognitive decline over 12 months was evaluated by means of changes in Mini Mental State Examination (MMSE) and AD A...